Although there are certain emotional and physical symptoms of substance use, do not immediately assume that the person is on drugs. There could be other reasons why he or she behaves unusually, so don't just ask frankly. 
Emotional and social signs
- Moodiness, excitement, anger, hostility, depression
- Constant lying and stealing
- Refusing to admit to the harmful effects of drugs
- Avoiding old friends or people who could confront them about behaviour changes
- Being secretive about themselves (like phonecalls, etc.)
- Having friends they do not want you to meet or talk about
- Being evasive about their whereabouts
- Loss of motivation
- No interest in everyday life
- Playing truant from school (skipping school, detention, careless about grades)
Physical signs
- Drowsiness
- Trembling
- Red eyes, dilated pupils
- Lack of interest in personal hygiene and appearance
- Slurred speech
- Loss of, or increase in appetite
- Uncoordinated movements
- Circles under the eyes
- Irregular sleeping habits
- Frequent colds and coughs
- Weight loss
- Sudden decrease in weight
images and informations courtesy of (UNODC (United Nation Office on Drugs and Crime) with edits by me :)
You should be careful when you see someone with these characteristics, but DON'T AVOID THEM! talk to them, nobody wants to be alone! Give them hope :)
Keep hoping, guys~ 
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